However, unlike the latter two drugs, orforglipron is administered as a once-a-day pill rather than an injection, which should make it much more. Lilly’s experimental drug orforglipron comes from the blockbuster class of diabetes/weight-loss meds called glucagon-like peptide-1 agonists (GLP-1 agonists) that include Ozempic and Wegovy.So far, neither of the oral weight loss drugs have demonstrated as high of an efficacy as Lilly’s tirzepatide, which was shown to reduce body weight, on average, by 22.5% after 72 weeks.Wegovy is FDA-approved specifically for weight loss. Liraglutide ( Saxenda) injection and semaglutide ( Ozempic) injection were originally approved for the treatment of type 2 diabetes. Table of contents Top drug in the works Other study medications Approved medications Best medication Bottom line References Mykola Sosiukin/iStock via Getty Images Plus Naltrexone-bupropion SR ( Contrave) – Each of these medications have been used to promote weight loss, but when used together can cause greater weight loss. Wegovy (semaglutide), Saxenda (liraglutide), and Contrave (naltrexone/bupropion) are common examples.

Several medications are already FDA-approved for weight loss.Both are injected drugs for weekly use that you. Ozempic was approved first for the treatment of type 2 diabetes, but in some cases it's also being used off-label as a weight loss drug.One agent that is available without a prescription is Alli ( orlistat ), a lower-dose version of the prescription drug Xenical. Medications lose weight There are very few proven choices in over-the-counter (OTC) or nonprescription medications for effective weight loss.

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